Dołączył: 07 Maj 2011
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Tongxinluo capsule combined with Simvastatin 34 cases of patients with high fat and the effect of hyperviscosity
Abstract Objective Tongxinluo capsule combined with Simvastatin on hyperlipidemia hyperviscosity clinical efficacy. Methods 67 cases of high fat and hyperviscosity were randomly divided into the Tongxinluo United simvastatin group (treatment group, n = 34) and single-service simvastatin group (control group, n = 33). Course of treatment was 8 weeks. Results There were significant improvement in lipid blood viscosity (P
Key words Tongxinluo capsule; simvastatin; hyperlipidemia; hyperviscosity
In recent years as people's living standards, in patients with hyperlipidemia were significantly increased. The changes in lipid levels and blood rheology and ischemic cardiovascular and cerebrovascular diseases are closely related. World Health Organization, due to abnormal blood lipid blood viscosity caused by cardiovascular disease and deaths from the disease account for all the first annual deaths, up to 1 500 million. So deal with hyperlipidemia and patients with hyperviscosity syndrome due to drug intervention. Tongxinluo capsule combined with Simvastatin significantly reduced in patients with high cholesterol and high blood viscosity state. In our hospital from July 2008 to June 2009 67 cases of patients with high fat and hyperviscosity two drugs in combination therapy efficacy, are as follows.
1 Materials and Methods
1.1 General information subjects the day before blood alcohol, low-fat diet, the next morning fasting venous blood taken, the use of SA-5000 automatic blood rheology instruments and automatic biochemical analyzer for detection. Determination of high shear blood viscosity, low shear viscosity, plasma viscosity,[link widoczny dla zalogowanych], hematocrit, triglyceride (TG),[link widoczny dla zalogowanych], total cholesterol (TC), collected 67 cases of blood viscosity and blood lipid test results are abnormal, aged 41 to 81 years , of which 36 males and 31 females. High cholesterol (TC> 5.72 mmol / L) 38 cases of high triglyceride (TG> 1.7 mmol / L) 29 patients were randomly divided into treatment group, 34 patients, 18 males and 16 females, mean age (56 ± 11 years). Control group, 33 patients were 18 males and 15 females, mean age (57 ± 11) years old. Selected cases were excluded thyroid,[link widoczny dla zalogowanych], liver and gallbladder diseases and diabetes, and kidney is affected lipid metabolism of drugs (such as thiazide diuretics, steroids, etc.). Two groups of age, sex, blood viscosity and blood test data, the difference was not statistically significant (P> 0.05),[link widoczny dla zalogowanych], comparable.
1.2 method selected two weeks before treatment patients have to disable the other lipid-lowering diet and drugs. The treatment group received Tongxinluo capsule (Shijiazhuang Yiling Pharmaceutical Co., Ltd. 0.38 g) three times a day, every 1.14 g of oral simvastatin (brand name Xin Lu,[link widoczny dla zalogowanych], Shandong Lukang Pharmaceutical Co., Ltd. Each 10 mg) 10 mg / d, Dayton clothing per night, single-service control group, simvastatin 10 mg / d, Dayton night clothes, and even served for 8 weeks.
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